2013;5:209ra151
The changing landscape emphasizes the importance of ongoing research, patient education, and smart market strategies to ensure the continued expansion and success of GLP-1 agonists in the dynamic field of diabetes treatments
When to consider adjusting your GLP-1 dose Sometimes constipation is severe enough that it affects quality of life despite implementing all the strategies above
3,4 GLP-1RAs mimic the action of endogenous GLP-1, activating GLP-1R, thereby enhancing insulin secretion, inhibiting glucagon release, delaying gastric emptying, and reducing food intake through central appetite suppression
You should contact your GP or healthcare provider if: Night sweats are severe, persistent, or worsening over time You experience unintentional weight loss beyond what is expected from Mounjaro therapy Night sweats are accompanied by fever, chills, or signs of infection You notice fatigue, weakness, or unexplained changes in appetite There are symptoms suggestive of hypoglycaemia , such as confusion, tremor, palpitations, or waking feeling unwell You develop new or unusual symptoms such as lumps, persistent cough, or changes in bowel habits You experience severe, persistent abdominal pain radiating to the back (seek urgent medical attention as this could indicate pancreatitis) These features may indicate underlying conditions that require investigation, such as infections (including tuberculosis), hyperthyroidism, lymphoma, or other systemic illnesses
